Asthma Phenotypes In Offspring
Asthma was defined based on the following question: Please write the years when your children were born, and tick YES if they have had any of the following: Asthma before 10 year Asthma after 10 years Hayfever/rhinitis Atopic eczema/skin allergies. Asthma before 10 years defined early-onset asthma and asthma after age 10 years defined later-onset asthma. Allergic asthma was defined by a positive answer to asthma and to hay fever non-allergic asthma as having asthma but not hay fever. Age 10 years was set as the cut-off point to separate childhood asthma from asthma with onset in early puberty or later in both sexes.
Infants under 2 years of age were excluded from analyses, as asthma diagnosis in this age group is unclear .
Is Hereditary Asthma Curable
No forms of asthma, be it hereditary asthma or occupational asthma caused by exposure to fumes, dust or other substances through your work, are fully curable. However, there are a number of effective medications and lifestyle measures that can be used to successfully manage and treat your symptoms.
Your doctor or asthma nurse will work with you to create an asthma treatment plan that suits you. This tailored approach works well, as no two cases of asthma are identical and it can affect people in different ways.
Modern treatments for asthma focus on trying to relieve symptoms and stop them from happening. Asthma inhalers are commonly prescribed for this. A reliever inhaler can be used to ease asthma symptoms that occur, whereas a preventer inhaler is prescribed to prevent the symptoms occurring. In some cases, you may be prescribed an inhaler that does both, known as a combination inhaler.
Your doctor will provide advice on how and when to take your inhalers. A brown inhaler is typically used on a daily basis, whereas you may only need to use a blue inhaler sporadically, especially as your asthma symptoms become better managed.
Sometimes tablets are prescribed, especially if inhalers alone arent fully controlling your symptoms.
There are also practical lifestyle steps that you can take, in conjunction with using your inhalers and taking medication as guided by your doctor.
These include:
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Links Between Parents’ And Children’s Asthma And Allergies
- Date:
- Wiley
- Summary:
- New research found that, compared with a father’s traits related to allergies and asthma, a mother’s traits create a higher risk that a child will develop these same traits in early childhood.
New research found that, compared with a father’s traits related to allergies and asthma, a mother’s traits create a higher risk that a child will develop these same traits in early childhood.
The Clinical & Experimental Allergy study included 685 parent-child trios.
“This study adds to the increasing evidence linking the pregnancy period to disease in early childhood. We find this discovery very interesting, as it circumvents any known or unknown genetic factors that could add to the heritability of asthma and allergies,” said senior author Hans Bisgaard, MD, DMSc, of the University of Copenhagen, in Denmark.
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Doseresponse Effect Of Paternal Pre
Both a fathers early smoking debut and a fathers longer smoking duration before conception increased non-allergic early-onset asthma in offspring, even with mutual adjustment and adjusting for number of cigarettes and years since quitting smoking . Early smoking debut was associated with more non-allergic early-onset offspring asthma even if the smoking stopped at least 5 years before the childs birth . A fathers smoking debut before age 11 years showed the greatest increased risk , followed by smoking debut ages 1114 and smoking debut after age 15 . Longer duration of smoking was also associated with an increased risk, up to 1.8-fold for those smoking for more than 10 years . Time of quitting before conception was not independently associated with non-allergic early-onset offspring asthma.
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What Are The Emergency Management Of An Asthmatic Patient
Emergency treatment
These can include: Short-acting beta agonists, such as albuterol. These are the same medications as those in your quick-acting inhaler. You may need to use a machine called a nebulizer, which turns the medication into a mist that can be inhaled deep into your lungs.
What environmental changes can the patient take to improve his her breathing with asthma?
Recommendations for exposure reduction include staying indoors, keeping windows and doors closed, using air conditioning, and perhaps HEPA room-air filters. After spending time outdoors, pollen-allergic patients should wash their hands and face, and should wash their hair daily to remove allergens.
Is asthma environmental or genetic?
It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment.
What Runs In Your Family
Genes are passed from parents to children. Every person has two sets of chromosomes in their cells. When a man and woman conceive a baby, one set of chromosomes from each parent combine to make up the DNA of their child. Remember: everyone has two copies of every gene.
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Heterogeneity Between Study Centres
Meta-analysis of the association between paternal pre-conception smoking and preconception welding with early-onset non-allergic asthma in offspring by study centre, adjusted for offspring age and paternal characteristics . Boxes show odds ratios and horizontal lines show 95% confidence intervals for each study centre, box size is proportional to number of study subjects, diamond shows combined estimate for all centres with 95% confidence interval from fixed effects meta-analysis.
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Asthma And Family History
Numerous studies have found that your family history can be a risk factor for the development of asthma. If one of your parents or siblings has asthma, then youre more likely to have it too. If both your parents have asthma, then this risk increases further. Youre also more likely to have other related atopic conditions, such as eczema, hay fever or food allergies.
This doesnt mean that youll definitely develop asthma if other members of your family have it, just that the genetics predispose you to a greater risk. Nor does it mean that you wont develop the condition if your relatives are all free of asthma.
Brain Development And Autism
The brain develops differently in autistic children compared with typically developing children.
In young children, the brain is developing all the time. Every time a child does something or responds to something, connections in the brain are reinforced and become stronger.
Over time, the connections that arent reinforced disappear theyre pruned away as theyre not needed. This pruning is how the brain makes room for important connections those needed for everyday actions and responses, like walking, talking or understanding emotions.
In autistic children, the brain tends to grow faster than average during early childhood, especially during the first three years of life. The brains of autistic babies appear to have more cells than they need, as well as poor connections between the cells.
Also, pruning doesnt seem to happen as much in autistic children. This means that information might be lost or sent through the wrong connections. The lack of pruning might also explain why the brain seems to be growing faster in autistic children than in typically developing children.
Its not yet clear what causes this difference in brain development.
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High Levels Of Fetal Testosterone
It has long been noted that the prevalence of Autism seems to be stronger in boys than in girls. It does not mean that girls are excluded from Autism, but instead that higher numbers of boys are diagnosed than girls. Science has indeed confirmed that the trait is male-typical, although not exclusive. The study says that high levels of testosterone in the amniotic fluid may be related to certain variables of brain function, like cognition and behavior. The information was compiled from routine amniocentesis. These findings confirm a previous hypothesis that Autism could be related to the male sex hormone. The theory states that children with extreme male brain, babies exposed to too much testosterone, show a reduced capacity to empathize and a stronger urge to systemize. Researchers say that this test was too small to be conclusive and that a much larger study is necessary to confirm the link between over productions of testosterone in the amniotic fluid and Autism.
Maternal Asthma And Offspring Asthma
The pooled analysis for the 33 total studies is summarized in figure 2. Children of asthmatic mothers are more likely than children of non-asthmatic mothers to develop asthma . The test for heterogeneity showed a non-significant p-value of 0.13, indicating that the studies had similar outcomes and were appropriate to be summarized in a meta-analysis. The funnel plot of OR versus standard error was symmetric , and Egger’s test was negative for publication bias . To ensure that no single study skewed the overall results, each study was removed one at a time and the summary OR recalculated. Removal of each individual study did not significantly alter the summary OR. All the recalculated summary odds ratios lay within the 95% confidence interval of the principal analysis .
Studies of maternal asthma as a risk factor of asthma.
Sizes of boxes represent inverse variance weights . Lines represent 95% confidence intervals.
Subgroup analysis was also performed based on quality measures. When analyzing only those papers which were based on physician diagnosed asthma similar but attenuated results were seen 2.85 . When analyzing those studies where the patient population was > /=5 year of age or those which were population based the summary OR was similar but elevated at 3.15 and 3.41 respectively.
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Reasons Autism Begins In Pregnancy
These days it is pretty hard to make sense of everything we see in the news and through social media. With so much contradictory information, inflamed personal views, misinterpretations, and assumptio
These days it is pretty hard to make sense of everything we see in the news and through social media. With so much contradictory information, inflamed personal views, misinterpretations, and assumptions about Autism and what causes, it can be easy to have our judgment clouded. Many of us are left wondering what the truth is and what isnt. While there are many beliefs and stigmas surrounding the definitive reasons that we are seeing an increase in Autism diagnosis, there has never been one single source identified as the culprit. According to experts in the field, there are many potential causes of Autism, but one thing that many of them have in common is a link between the disorder and pregnancy. Science is telling us in so many words, that Autism probably begins in the womb, in most cases.
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Paternal Asthma And Offspring Asthma
Similar analysis was performed on the paternal asthma data. The analysis is summarized in figure 3. Children of asthmatic fathers are more likely to develop asthma than those of non-asthmatic fathers . The test for heterogeneity showed a non-significant p-value of 0.06. The funnel plot of OR versus standard error was symmetric , and Egger’s test was negative for publication bias . To ensure that no single study skewed the overall results, each study was removed one at a time and summary OR recalculated. Removal of each individual study did not significantly alter the summary OR .
Studies of paternal asthma as a risk factor of asthma.
Sizes of boxes represent inverse variance weights . Lines represent 95% confidence intervals.
Subgroup analysis was also performed in the same groups as were used in the maternal asthma data. When analyzing only those papers which were based on physician diagnosed asthma similar results were seen 2.48 . When analyzing those studies where the patient population was > /=5 year of age or those which were population based the summary OR was similar but elevated at 2.60 and 2.56 respectively Heterogeneity was possible in the former subgroup analysis as p=0.02.
When analyzing those studies that adjusted for potential confounding or those where the patient population was > /=18 year of age similar but elevated summary odds ratio were seen and 2.72 respectively).
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What Genetic Testing May Tell You
Genetic testing cannot tell you anything definitive about autism at this point it may be able to tell you about some other genetic conditions, should you be concerned. One of these tests may inform you of:
- The chances that your future children may develop autism.
- What kinds of services and treatment may best benefit your child.
- Other health issues or concerns related to the genetic mutation that caused your childs autism. Some genetic disorders have been associated with autism. These include tuberous sclerosis, benign tumors that grow on the brain and other organs, and Fragile X syndrome, a condition that causes intellectual disabilities.
What To Know About Asthma And Genetics
Genetic predisposition is one of the strongest risk factors for developing asthma.
While no one is born with asthma itself, you may be born with genes that dictate whether youll get it as an infant or young child.
In fact, its estimated that children are up to 3 times more likely to develop asthma if their mothers have it, and 2.5 times more likely if their fathers do.
However, theres no guarantee that a genetic disposition will automatically mean you get asthma.
One study on twins with asthma found that 66 percent of cases were linked to environmental factors, while the other 34 percent were genetic. Another 2019 review states that the risk of twins developing asthma because of their genes ranges between 55 and 90 percent.
Other supports the fact that while one sibling might get asthma from their parents, other siblings may not.
Due to the fact that asthma is
Even if asthma doesnt run in your family, its still possible to develop this condition at some point in your lifetime.
Other possible causes and risk factors for asthma development include:
- having a personal or family history of allergies
- a history of autoimmune diseases
- having hay fever or eczema
- premature birth
- smoking or frequent exposure to cigarette smoke
- regular exposure to air pollution, gasses, and chemical fumes
- hormonal changes in women during menopause
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What Helps Asthma Without An Inhaler
Read on to learn more.
- Sit up straight. Sitting upright can help keep your airways open.
- Remain calm. Try to remain as calm as you can while youre having an asthma attack.
- Steady your breathing. Try to take slow, steady breaths during your attack.
- Move away from triggers.
Which objective measurement is the best at assessing asthma control?
What are the 4 categories of asthma?
The EPR-3 guideline classification divides asthma severity into four groups: intermittent, persistent-mild, persistent-moderate, and persistent-severe.