Asthma Vs Copd Over Time
- Asthma is usually considered a periodic disease. This means symptoms only occur sometimes. COPD is usually considered a persistent disease. This means that symptoms may appear to some degree all the time.
- Periods between asthma attacks may last days, weeks, months, or even years. In this way, asthma can seem to go into remission in some people. COPD flare-ups may also be periodic in this way. But, COPD does not go into remission.
- Asthma usually does not progress over time. COPD is generally considered a progressive disease. But, this progression may be slowed with a proper diagnosis and aggressive treatment.
- Speaking of diagnosis, both diseases may be confirmed with a test called a pulmonary function test . The test will show if triggers cause airflow limitation. It can also show if this airflow limitation is reversible or not reversible .
- Asthma medicines are used to prevent and control asthma symptoms. COPD medicines are used to allay symptoms and slow the progression of the disease.
Clinical Trials Involving The Anticholinergic Drug From Boehringer Ingelheim
The clinical development programme for spiriva included more than 25,000 patients. Phase III trials of spiriva included two one-year placebo-controlled trials, two one-year active-controlled trials and two six-month placebo controlled trials.
The studies recruited 2,663 patients, aged 39 to 87 years. The most common adverse reaction in the trials was dry mouth.
Two additional trials, including a six-month randomised placebo controlled study in 1,829 patients, were conducted. The second study was a four-year trial, called Uplift, carried out in 5,992 patients.
The trial showed that spiriva improved lung function and quality of life for patients. The patient population and adverse reaction were similar to that of the one-year and six-month trials.
Based on the results of the Uplift study, the FDA approved spiriva for reduction of exacerbations in patients with COPD.
In March 2011, results from a new one-year study, POET-COPD, were announced. The study was conducted to compare the affects of Salmeterol with spiriva in reducing COPD exacerbations . It recruited 7,376 patients with moderate to severe COPD. Results from the study indicated that spiriva was superior in reducing COPD exacerbations, compared to Salmeterol.
Side Effects In Children
Spiriva Respimat is used to improve lung function in children with asthma who are ages 6 years and older. This drug is used as a maintenance treatment to control asthma symptoms over time.
In clinical studies, there were no differences in the common side effects seen in children and teenagers using Spiriva Respimat compared to adults using the drug.
Spiriva HandiHaler isnt approved for use in children.
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If You Are Living With Copd Chances Are You Are Using Spiriva
June 20, 2017 By jmartinez
Once you hit 40, your body starts to really take a beating. lets face it you are not a spring chicken anymore. The recovery from injury or sickness is greater. A pulled hamstring that was once a week recovery takes about a month. And that snap, crackle, pop sound is your body and not rice krispies. This leads me to a disease that really begins to hit hard once you are about 40 and can be really debilitating as you get into your 60s. It is called COPD or chronic obstructive pulmonary disease. This is not a single disease but a combination of diseases all rolled up into one. If you suffer from this, there is a good chance you might be using Spiriva to manage it.
Before Taking This Medicine
You should not use Spiriva if you are allergic to tiotropium or ipratropium .
To make sure this medicine is safe for you, tell your doctor if you have ever had:
an enlarged prostate or urination problems.
Tell your doctor if you are pregnant. It is not known whether tiotropium will harm an unborn baby. However, having uncontrolled asthma during pregnancy may cause premature birth, a low birth weight baby, or complications such as eclampsia . The benefit of treating asthma may outweigh any risks to the baby.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Spiriva Respimat is not approved for use by anyone younger than 6 years old.
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Drug Forms And Administration
Spiriva comes in two forms that are taken as follows:
- Spiriva HandiHaler. This form of Spiriva comes as powder-filled capsules that are taken using an inhaler. It should be taken as two inhalations , using just one powder capsule for both puffs, once each day.
- Spiriva Respimat. This form of Spiriva comes as a liquid solution inside an inhaler. The strength of Spiriva Respimat that youre given depends on whether youre taking it for asthma or COPD. This drug should be taken as two inhalations once each day.
Incruse Ellipta comes as an inhaler that contains a powder. It should be taken as one inhalation once each day.
Side Effects And Risks
Spiriva and Incruse Ellipta both contain drugs that belong to a class of medications called anticholinergic agents. Therefore, these medications can cause very similar side effects. Below are examples of these side effects.
More common side effects
These lists contain examples of more common side effects that can occur with either form of Spiriva, with Incruse Ellipta, or with any of the drugs .
- Can occur with Spiriva:
- blurry vision
Serious side effects
This list contains examples of serious side effects that can occur with both Spiriva and Incruse Ellipta :
- severe allergic reaction
- paradoxical bronchospasm
- acute narrow-angle glaucoma
- being unable to pass urine
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How To Use It
Spiriva Respimat is for inhalation use only.
Make sure that you know how to use your Spiriva Respimat inhaler properly. The instructions for use are provided at the end of this leaflet.
Carefully read the instructions for use and follow the diagrams that show you how to use the Spiriva Respimat inhaler.
If you do not understand the instructions on how to use the Spiriva Respimat inhaler, ask your doctor or pharmacist for help.
Use the Spiriva Respimat inhaler supplied in the pack to breathe in the solution containing the medicine from the Spiriva Respimat cartridge.
Insert the Spiriva Respimat cartridge into the Spiriva Respimat inhaler to prepare the inhaler for first use.
The Spiriva Respimat inhaler releases a mist of solution slowly and gently, making it easy to inhale it into your lungs where it is needed. The mist containing the medication is released by pressing the dose release button.
How Should I Use This Medication
For adults and children 18 years of age and older, the recommended dosage of tiotropium is to inhale the contents of one 18 µg capsule once daily through the HandiHaler® inhalation device.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Take this medication at the same time each morning. The capsule shell should be discarded after the medication has been taken. Do not swallow the capsule shell.
Your doctor or another health care professional, such as your pharmacist, should teach you how to use the HandiHaler® inhalation device. If you are unsure of how to use the device, contact your doctor or pharmacist.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
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How Should I Use Spiriva
Use Spiriva exactly as prescribed by your doctor. The usual dose of this medicine is 2 inhalations through the mouth once daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Spiriva is not a rescue medicine. It will not work fast enough to treat a COPD flare-up. Your doctor may prescribe a fast-acting inhalation medicine to treat a bronchospasm attack. Tell your doctor if it seems like your medications don’t work as well.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Any child using Spiriva Respimat should be supervised by an adult while using this medicine.
Spiriva HandiHaler is packaged in capsules that come with a special inhaler device. Each time you use the medicine, load a capsule into the device and click the mouthpiece closed. Push the button on the side of the device to pierce the capsule and release the medicine into the inhalation chamber. You will need 2 inhalations to get the full dose from 1 capsule.
Do not take the capsule by mouth. Spiriva capsules are for use only in the HandiHaler device. Use only 1 capsule at a time. Do not use the HandiHaler device to take any other medicine.
To be sure this medicine is helping your condition, your lung function will need to be tested on a regular basis.
If I Have Arthritis In My Hands Will I Be Able To Use The Spiriva Inhaler
Yes, youll probably be able to. In fact, if you have arthritis, talk with your doctor about using the Spiriva Respimat inhaler.
While Spiriva comes as either the HandiHaler or Respimat inhaler, the Respimat inhaler is certified by the Arthritis Foundation as being easy to use for people who have arthritis in their hands.
If youd like to know more about the ease of using Spiriva, talk with your doctor.
Spiriva contains the active drug tiotropium bromide. It belongs to a class of drugs called anticholinergic agents.
Over time, Spiriva works to relax and open up your airways. It does this by binding to certain receptors in your airways. Once your airways are opened, air can flow more easily through them, making it easier for you to breathe.
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Large International Study Of Copd Drug Finds Two Types Of Inhalers Equally Safe And Effective
An international study led by a Johns Hopkins pulmonary expert finds that the drug tiotropium , can be delivered safely and effectively to people with chronic obstructive pulmonary disease in both “mist” and traditional “dry powder” inhalers.
The new Respimat inhaler, which delivers the drug in a mist form, is approved for use in Europe but not in the United States. The traditional inhaler, known as a HandiHaler, uses a dry powder form of the drug and is widely used in the U.S.
The study comparing the two drug-delivery systems was a randomized, double-blind, prospective trial conducted at 1,200 sites in 50 countries with more than 17,000 COPD patients. Results of the study are described in an article in the New England Journal of Medicine on Sept. 8, 2013, and are scheduled to be presented the same day at the European Respiratory Society meeting in Barcelona, Spain, by Robert Wise, M.D., professor of medicine at the Johns Hopkins University School of Medicine.
“This was a much-awaited study, because previous, smaller studies had raised the question of whether there was an increased risk of death with the newer tiotropium device, says Wise, who is the lead author of the study. “We needed a very large trial to answer the question.”
The researchers randomly assigned participants to one of three groups. Two different doses of the drug were studied among those who used the new Respimat inhaler.
My Spiriva Respimat Sprays Automatically
Was the cap open when you turned the clear base? Close the cap, then turn the clear base.
Did you press the dose-release button when turning the clear base? Close the cap, so the dose-release button is covered, then turn the clear base.
Did you stop when turning the clear base before it clicked? Turn the clear base in a continuous movement until it clicks .
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Can Inhalers Like Spiriva Cause Dementia
Its not known for sure if using drugs similar to Spiriva can increase your risk for dementia.
One study looked at 58,769 people diagnosed with dementia who had taken anticholinergic agents earlier in their life.
This study didnt determine whether the anticholinergic drugs caused the peoples dementia. However, the use of anticholinergics was associated with higher risk for dementia, especially in middle-aged and older adults.
More research is needed to know whether using anticholinergic drugs, such as Spiriva, can increase the risk for dementia later in life.
Whats The Best Inhaler For Copd
Thats a tough question. It depends on a few factors, such as severity and type of symptoms, your medical history, and other medicines you take. Your healthcare provider can determine which inhaler is best for you.
There are dozens of inhaled medications on the market. Here are a few commonly prescribed inhaled treatments for COPD:
LAMAs : Incruse Ellipta , Seebri , Spiriva Respimat or Handihaler, Tudorza Pressair
Inhaled corticosteroids:Qvar RediHaler , Pulmicort Flexhaler
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Things You Must Not Do
Do not use Spiriva Respimat to treat any other complaints unless your doctor tells you to.
Do not give this medicine to anyone else, even if they have the same condition as you.
Do not take any other medicines for your breathing problems without checking with your doctor.
Do not use Spiriva Respimat to relieve an acute attack of breathlessness or wheezing.
If you become wheezy or tight in the chest before your next dose of Spiriva Respimat is due, use a ‘reliever puffer’ in the usual way.
Spiriva Respimat should only be used as the maintenance treatment of your COPD or asthma.
Do not stop using your medicine or lower the dosage without checking with your doctor. If you stop using it suddenly or lower the dosage, the signs and symptoms of your COPD may worsen.
Do not take Spiriva Respimat more frequently than once daily.
Spiriva Tiotropium Bromide Capsules
Spirivas active substance tiotropium bromide is an antimuscarinic agent with an affinity towards M1 to M5 muscarinic receptors. It works by inhibiting M3 receptors known to cause bronchitis.
Spiriva is available as capsules containing tiotropium bromide in dry powder form mixed with lactose monohydrate. The HandiHaler device is used to inhale the powder contained in the capsule. The inhalation device delivers the powder at the rate of 20l/min.
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Are Spiriva Handihaler Or Spiriva Respimat Used Twice Daily
No, Spiriva HandiHaler and Spiriva Respimat are not used twice daily. Both forms of the drug should be used once per day. But both the Spiriva HandiHaler and Spiriva Respimat will both require two inhalations taken once daily.
Certain other drugs used to treat asthma or chronic obstructive pulmonary disease may be used twice daily, such as Advair Diskus . To learn more about how Spiriva and Advair Diskus are alike and different, check out this article.
I Cannot Turn The Clear Base
Did you turn the clear base already?
If the clear base has already been turned, follow steps âOPENâ and âPRESSâ under âDaily useâ to get your medicine.
Is the dose indicator on the Spiriva Respimat pointing to zero? The Spiriva Respimat inhaler is locked after 60 puffs . Prepare and use your new Spiriva Respimat inhaler.
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Incruse Ellipta Vs Spiriva: Differences Similarities And Which Is Better For You
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According to the American Lung Association, chronic obstructive pulmonary disease, or COPD, is the third leading cause of death by disease in the U.S. Over 16 million people have been diagnosed with COPD, with millions more likely affected but not yet aware. COPD is a chronic inflammatory lung disease. Patients with COPD often experience difficulty breathing, coughing, wheezing, and mucus production. COPD includes emphysema and chronic bronchitis. Two common medications used to manage COPD are orally inhaled medications called Incruse Ellipta and Spiriva.
Incruse Ellipta and Spiriva are both brand-name medications indicated for the long-term maintenance treatment of COPD. Both drugs are approved by the U.S. Food and Drug Administration . They are classified in a group of medications called anticholinergics. They work by relaxing the muscles in the lungs, making breathing easier.
Although Incruse Ellipta and Spiriva are both anticholinergics used for COPD, they are not exactly the same. Continue reading below to learn more about each medication.
What Form Does This Medication Come In
Each light green, hard gelatin capsule printed “TI 01” on one side and the Boehringer Ingelheim company logo on the other side contains tiotropium 18 µg. Nonmedicinal ingredients: lactose is used as a filler. Capsule shells are made of gelatin.
The HandiHaler® inhalation device is a grey reusable plastic device that is especially designed for administering Spiriva® capsules.
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More Common Side Effects
The more common side effects of Spiriva can include:
- upper respiratory tract infection, such as the common cold
- dry mouth
- increased heart rate
- blurry vision
Most of these side effects may go away within a few days or a couple of weeks. If theyre more severe or dont go away, talk with your doctor or pharmacist.