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Does Singulair Help With Asthma

How Should This Medicine Be Used

Asthma treatment-Asthma drugs-Leukotriene antagonists-singulair

Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth. Montelukast is usually taken once a day with or without food. When montelukast is used to treat asthma, it should be taken in the evening. When montelukast is used to prevent breathing difficulties during exercise, it should be taken at least 2 hours before exercise. If you are taking montelukast once a day on a regular basis, or if you have taken a dose of montelukast within the past 24 hours, you should not take an additional dose before exercising. When montelukast is used to treat allergic rhinitis, it may be taken at any time of day. Take montelukast at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take montelukast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not use montelukast to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack. If your asthma symptoms get worse or if you have asthma attacks more often, be sure to call your doctor.

Montelukast controls the symptoms of asthma and allergic rhinitis but does not cure these conditions. Continue to take montelukast even if you feel well. Do not stop taking montelukast without talking to your doctor.

Enrollment Procedures And Study Setting

Following enrollment, two women and two men were excluded from the analysis for no-show at the follow-up visit. The final study population included 10 males between 23 and 43 years old and 11 age-matched females among the participants, there were two mild smokers with a smoking history of 8.2 + 2.9 pack/years. No woman was taking oral or intrauterine contraceptives. Obesity, defined as a body mass index 30 kg/m2, was present in two females . At the moment of the enrollment, all the subjects were treated using the Step 2 approach recommended by Consensus-based Asthma Symptom Control : regular low dose of ICS plus as-needed short acting beta2-agonists . Since the asthma was non- or partially controlled based upon daytime asthma symptoms, night waking due to asthma, as-needed use of SABA, activity limitation due to the symptoms, a step-up approach was required at baseline visit. According to the Step 3 approach, the subjects were switched to a low-dose maintenance therapy with ICS + MS , plus as-needed SABA or low-dose ICS/LABA.

Table 1 Demographic characteristics of study participants.

Baseline and End of Study Visits

At enrollment, prior to the MS addition to ICS therapy, the values for FEV1.0, FVC, fraction of FeNO, and eosinophils levels were recorded, together with the results of the asthma control test . Patients were seen by their assigned physician in an outpatient setting at enrollment and 13 weeks after the enrollment.

Assessments

Does Singulair Help With Congestion

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What Is Singulair How Does It Work

Singulair, or montelukast, is a leukotriene receptor antagonist .

Leukotrienes are released by the immune system in response to allergens, such as pollen, and promote inflammation, bronchoconstriction , breathing difficulties, and other allergy symptoms.

The active ingredient, montelukast, in leukotriene receptor antagonists like Singulair binds to these receptors and opposes their function.

Singulair is usually used to prevent asthma attacks and treat seasonal allergies. Singulair isnt effective for acute asthma attacks or sudden, extreme allergic reactions. Instead, its commonly used long-term for maintenance purposes and is usually safe for extended, regular use.

Gender Differences In Asthma Control Tests Among Patients Treated With Montelukast Plus Inhaled Corticosteroids

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At baseline visit, there were no significant differences between women and men in ACT score. After 13 weeks of add-on therapy with MS, we observed a marked improvement in ACT score compared with the baseline one. The ACT score was significantly higher in women than men . Asthmatic women treated with MS + ICS showed a better control of symptoms compared with men treated with the same dose and therapeutic approach . The higher effectiveness of MS + ICS in women vs. men is highlighted by the Delta Percentage , which confirms the achievement of a better control of symptoms in women respect to men .

Figure 1 ACT evaluation. ACT evaluations in montelukast treated group in women and in men at the enrollment visit and at the end of study . ACT in treated women and in men. Results were shown as means ± SEM. The statistical tests used in these analyses were two-way analysis of variance followed by Students t-test. *P < 0.05 ***P < 0.001.

Table 2 Data results of FEV1.0, FVC, FeNO, ACT, EOS, and % indicated as mean ± SEM.

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What Should I Tell My Healthcare Provider Before Taking Singulair

Before taking Singulair, tell your healthcare provider if you:

  • are allergic to aspirin
  • have phenylketonuria. Singulair chewable tablets contain aspartame, a source of phenylalanine
  • have any other medical conditions
  • are pregnant or plan to become pregnant. Talk to your doctor if you are pregnant or plan to become pregnant, as Singulair may not be right for you.
  • are breast-feeding or plan to breast-feed. It is not known if Singulair passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Singulair.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how Singulair works, or Singulair may affect how your other medicines work.

How Much To Take

For patients with asthma and/or seasonal allergic rhinitis, take SINGULAIR only when prescribed by your doctor.

For adults and teenagers 15 years and older, the dose is one 10 mg film-coated tablet taken each day.

For children 6 to 14 years old, the dose is one 5 mg chewable tablet taken each day.

For children 2 to 5 years old, the dose is one 4 mg chewable tablet taken each day.

For patients with asthma, take SINGULAIR once a day in the evening.

For patients with seasonal allergic rhinitis, take SINGULAIR once a day as prescribed by your doctor.

Follow all directions given to you by your doctor carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the box, ask your doctor or pharmacist for help.

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Singulair Asthma Tablets : An Unconventional Asthma Treatment

Singulair tablets developed and marketed by Merck Sharp & Dohme is an unconventional asthma treatment classified as leukotriene receptor antagonist. The mechanism of action of this type of asthma medicine relies on the inhibition of the function of substance leukotriene that is naturally produced within the lungs and is thought to be directly related to the onset of asthma. Singulair tablets achieved amazing success and are now widely sold throughout the United Kingdom, being available even through numerous online clinics, so if youre not a big fan of waiting in line at the pharmacy, you can also choose to buy Singulair online simply, no matter where are you within the UK.

Singulair Users Who Died By Suicide:

Does Taking Montelukast Help Improve My Asthma?

Names left to right, top to bottom: Cody , Sara , Harry , Izaiah , Nick

NEW WARNINGS, LITTLE AWARENESS

Warnings the drug could cause depression, aggression, and suicide began appearing in the package insert for Singulair in 2008, a decade after the drug was put on the market, but the risks were not generally advertised.

According to the FDA, side effects for Singulair and its generics including suicidal thoughts and actions, agitation, aggressive behavior or hostility, attention problems, bad or vivid dreams, depression, disorientation, or confusion, feeling anxious, hallucinations including seeing or hearing things that are not there, irritability, memory problems, obsessive-compulsive symptoms, restlessness, sleepwalking, stuttering, tremor or shakiness, trouble sleeping and uncontrolled muscle movements.

In September of 2019, the FDA held a public meeting titled ‘Neuropsychiatric Events with the Use of Montelukast in Pediatric Patients.’ Montelukast is the generic of Singulair.

The FDA provided data showing more than 10,000 nervous system and psychotic events attributed to Singulair had been reported to the agency through their ‘FDA Adverse Event Reporting System.” FAERS is a database where the public and health care professionals can report problems with a medication. Some health experts at the meeting believe the thousands of reports represent only a fraction of the actual number of problems experienced by patients.

Included in the FDA’s warning:

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Can I Take Zyrtec Singulair And Flonase At The Same Time

Question: If someone is using a nasal steroid spray, such as Nasonex or Flonase, is it okay or even desirable to also use an oral antihistamine such as Zyrtec or Claritin? Answer: Yes, both antihistamines and nasal steroids can be used, depending on the clinical symptoms and the response to treatment.

Report Problems To The Food And Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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When You Must Not Take It

Do not take SINGULAIR if:

  • you have an allergy to SINGULAIR or any of the ingredients listed at the end of this leaflet
  • the packaging is torn or shows signs of tampering
  • the expiry date on the pack has passed.If you take this medicine after the expiry date has passed, it may not work.

If you are not sure whether you should start taking SINGULAIR, talk to your doctor.

Do not give SINGULAIR to children under 2 years of age. Safety and effectiveness in children younger than 2 years of age have not been studied.

In studies investigating the effect of SINGULAIR on the growth rate of children, it was shown that SINGULAIR did not affect the growth rate of children when given for up to 56 weeks in one study.

What Are Common Side Effects Of Singulair

Sun and Singulair

For both adults and children, the most common side effects of Singulair involve the respiratory system . Heres a list of Singulair side effects, from most to least common:

  • Upper respiratory infection like the common cold

  • Fever

  • Runny nose

  • Sinus infection

As far as long-term Singulair side effects, the side effects you might have from Singulair dont change much even with longer treatment.

Stopping Singulair suddenly typically doesnt cause withdrawal symptoms that can make your asthma worse. But to be on the safe side, talk to your doctor before stopping.

Very rarely , Singulair can cause more serious side effects like allergic reactions, joint and muscle pain, or heart palpitations. If you notice any of these symptoms, tell your doctor right away.

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Are There People Who Should Not Take Singulair

Singulair is not indicated for treating asthma attacks. If you are allergic to any ingredient in Singulair, you should not take this medication.2

Tell your health care provider if you are allergic to aspirin or have phenylketonuria.2 Tell your health care provider about any prescription or over-the-counter medications or supplements that you take.

Singulair has not been well studied in pregnant or breastfeeding women.2 Little is known about whether this medication passes into breast milk. Talk to your doctor about if you become pregnant or wish to breastfeed while taking Singulair.

For more on Singulair, see full prescribing information.

Side Effects Of Montelukast

Like all medicines, montelukast can cause side effects. Often, side effects can go, or improve, after two to three weeks of taking the medicine.

  • Common side effects include diarrhoea, stomach-ache, sore throats and infections.
  • Less common side effects include sleep issues such as insomnia, nightmares or sleepwalking, and mood changes such as anxiety, depression, and irritability.
  • Very rare potential side effects include severe mental health disturbances and suicidal thoughts.

Severe mental distress is an extremely rare side effect, but where it has happened it is extremely worrying and upsetting, says Dr Andy Whittamore, Asthma UKs in-house GP.

  • If you, or your child, show signs that montelukast is affecting your mood talk to your GP or asthma nurse as soon as possible.
  • If you or your child show signs of extreme distress, or have suicidal thoughts, stop taking the medicine immediately. Call 999 or go to A& E.

Always read the patient information leaflet so youre aware of what side effects to look out for, and when you need to go straight back to your GP or asthma nurse.

You can report any serious side effects yourself through the yellow card scheme. Or you can ask your doctor to do it for you.

Get help urgently if montelukast is affecting your mood

If you feel extremely distressed, or suicidal, stop taking the medicine. Get immediate help by calling 999 or going to your nearest A& E.

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Can Montelukast Cause Problems

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with montelukast. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common montelukast side-effects What can I do if I experience this?
Tummy pain, feeling sick , diarrhoea Speak with your doctor if this continues
Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
Throat and chest infections, high temperature , skin rash If troublesome, speak with your doctor

Important: if you get any of the following symptoms, please let your doctor know straightaway. These can be a sign of a very rare but serious disorder called Churg-Strauss syndrome: flu-like symptoms, tingling feelings or numbness in your arms or legs, difficulties with breathing, and skin rash.

Taking montelukast can sometimes affect your mood or behaviour, such as causing nightmares or other sleeping problems, anxiety, depression, agitation, irritability or restlessness. If you think you are being affected in this way, speak to your doctor for advice.

Safety Profile Of Montelukast

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The safety profile of montelukast has been well evaluated in the many long-term studies on large groups of adult and paediatric patients, and no significant or considerable side effects have been reported . A recent review on more than 2700 children and adolescents concluded that the clinical and laboratory safety profile for montelukast was similar to that observed for placebo or active control/usual care therapies, and that the safety profile of montelukast did not change with long-term use .

Since the beginning of the use of montelukast, several case reports on the occurrence of a Churg-Strauss syndrome have been reported. These cases have been considered as being due to the loss of some masking effect of high-dose ICS or oral corticosteroids, which were reduced after the addition of montelukast, with subsequent manifestation of full clinical features of the systemic vasculitis. A report on a large number of patients with CSS has been described in a recent paper, showing that montelukast use was associated with a 4.5-fold risk of CSS onset within 3 months, although this effect might be confounded by the escalation in asthma therapy before CSS onset .

More recently, some concern was raised regarding the possibility of greater suicide rate in patients taking montelukast, but the revision of 116 clinical studies showed that the frequency of behaviour-related adverse experience and suicides in patients treated with montelukast was no different from control groups .

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Adult Allergies: Can You Get Allergies At Any Age

Additional side effects include an increased tendency to bleed, low blood platelet count, allergic reactions, dizziness, drowsiness, numbness or pins and needles, seizures, and heart palpitations. People may also experience heartburn or indigestion, vomiting, hepatitis, bruising, and/or skin reactions. In some cases, people may have pain in their joints or muscles, muscle cramps, tiredness, and swelling, and in children, bed-wetting may occur.

If you experience any adverse effects while taking Singulair, its important to talk to your healthcare provider. People who have asthma and experience worsening symptoms when they take aspirin should avoid aspirin and non-steroidal anti-inflammatory drugs while taking Singulair.

People who are allergic to aspirin or have a condition called phenylketonuria should talk to their healthcare providers to get medical advice about the possible pros and cons of taking Singulair. Tell your provider about any other medical conditions you may have. Women who are pregnant or plan to become pregnant should also discuss using Singulair with their healthcare provider. Lastly, while there is little risk to the baby if you are breastfeeding, know that Singulair is present in breast milk. Discuss this with your healthcare provider.

There are a few drug interactions to mention. Taking Singulair with gemfibrozil may increase your blood concentration of Singulair. Conversely, drugs like lumacaftor and ivacaftor may lower Singulair levels.

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